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  4. Astrid D. Haase, M.D., Ph.D., Stadtman Tenure-Track Investigator
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Astrid D. Haase, M.D., Ph.D.
Astrid Haase.
Section Chief: RNA Biology Section, Laboratory of Cell & Molecular Biology
Scientific Focus Areas: Chromosome Biology, Developmental Biology, Genetics and Genomics, Molecular Biology and Biochemistry, RNA Biology

Publications

A selection of recent and significant publications can be viewed below.

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Hierarchical length and sequence preferences establish a single major piRNA 3'-end.
Stoyko D, Genzor P, Haase AD.
iScience (2022 Jun 17) 25:104427. Abstract/Full Text
Functional editing of endogenous genes through rapid selection of cell pools (Rapid generation of endogenously tagged genes in Drosophila ovarian somatic sheath cells).
Meng Q, Stoyko D, Andrews CM, Konstantinidou P, Genzor P, O T, Elchert AR, Benner L, Sobti S, Katz EY, Haase AD.
Nucleic Acids Res (2022 Aug 26) 50:e90. Abstract/Full Text
Cellular abundance shapes function in piRNA-guided genome defense.
Genzor P, Konstantinidou P, Stoyko D, Manzourolajdad A, Marlin Andrews C, Elchert AR, Stathopoulos C, Haase AD.
Genome Res (2021 Nov) 31:2058-2068. Abstract/Full Text
Aberrant expression of select piRNA-pathway genes does not reactivate piRNA silencing in cancer cells.
Genzor P, Cordts SC, Bokil NV, Haase AD.
Proc Natl Acad Sci U S A (2019 Jun 4) 116:11111-11112. Abstract/Full Text
Decoding the 5' nucleotide bias of PIWI-interacting RNAs.
Stein CB, Genzor P, Mitra S, Elchert AR, Ipsaro JJ, Benner L, Sobti S, Su Y, Hammell M, Joshua-Tor L, Haase AD.
Nat Commun (2019 Feb 19) 10:828. Abstract/Full Text

Additional Publications

A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements.
Haase AD.
Stem Cells Int (2016) 2016:7595791. Abstract/Full Text
Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.
Yang M, Haase AD, Huang FK, Coulis G, Rivera KD, Dickinson BC, Chang CJ, Pappin DJ, Neubert TA, Hannon GJ, Boivin B, Tonks NK.
Mol Cell (2014 Sep 4) 55:782-90. Abstract/Full Text
The making of a slicer: activation of human Argonaute-1.
Faehnle CR, Elkayam E, Haase AD, Hannon GJ, Joshua-Tor L.
Cell Rep (2013 Jun 27) 3:1901-9. Abstract/Full Text
The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.
Ipsaro JJ, Haase AD, Knott SR, Joshua-Tor L, Hannon GJ.
Nature (2012 Nov 8) 491:279-83. Abstract/Full Text
The structure of human argonaute-2 in complex with miR-20a.
Elkayam E, Kuhn CD, Tocilj A, Haase AD, Greene EM, Hannon GJ, Joshua-Tor L.
Cell (2012 Jul 6) 150:100-10. Abstract/Full Text
Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.
Haase AD, Fenoglio S, Muerdter F, Guzzardo PM, Czech B, Pappin DJ, Chen C, Gordon A, Hannon GJ.
Genes Dev (2010 Nov 15) 24:2499-504. Abstract/Full Text
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.
Trabucchi M, Briata P, Garcia-Mayoral M, Haase AD, Filipowicz W, Ramos A, Gherzi R, Rosenfeld MG.
Nature (2009 Jun 18) 459:1010-4. Abstract/Full Text
TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing.
Haase AD, Jaskiewicz L, Zhang H, Lainé S, Sack R, Gatignol A, Filipowicz W.
EMBO Rep (2005 Oct) 6:961-7. Abstract/Full Text
TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells.
Vietor I, Vadivelu SK, Wick N, Hoffman R, Cotten M, Seiser C, Fialka I, Wunderlich W, Haase A, Korinkova G, Brosch G, Huber LA.
EMBO J (2002 Sep 2) 21:4621-31. Abstract/Full Text
Last Reviewed March 2024