Susanne Neumann, Ph.D.

• Senior Associate Scientist: Laboratory of Endocrinology & Receptor Biology
• Senior Associate Scientist (On Detail): Office of Scientific Director

Scientific Focus Areas: Cell Biology, Molecular Biology and Biochemistry, Molecular Pharmacology

susanne.neumann@nih.gov 301-451-6307 Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease.

Krieger CC, Sui X, Kahaly GJ, Neumann S, Gershengorn MC.

J Clin Endocrinol Metab (2022 Mar 24) 107:e1653-e1660. Abstract/Full Text

Targeting TSH and IGF-1 Receptors to Treat Thyroid Eye Disease.

Neumann S, Krieger CC, Gershengorn MC.

Eur Thyroid J (2020 Dec) 9:59-65. Abstract/Full Text

Is There Evidence for IGF1R-Stimulating Abs in Graves' Orbitopathy Pathogenesis?

Krieger CC, Neumann S, Gershengorn MC.

Int J Mol Sci (2020 Sep 8) 21. Abstract/Full Text

β-Arrestin 1 in Thyrotropin Receptor Signaling in Bone: Studies in Osteoblast-Like Cells.

Boutin A, Gershengorn MC, Neumann S.

Front Endocrinol (Lausanne) (2020) 11:312. Abstract/Full Text

TSH/IGF1 receptor crosstalk: Mechanism and clinical implications.

Krieger CC, Neumann S, Gershengorn MC.

Pharmacol Ther (2020 May) 209:107502. Abstract/Full Text

Thyrotropin, but Not Thyroid-Stimulating Antibodies, Induces Biphasic Regulation of Gene Expression in Human Thyrocytes.

Jang D, Morgan SJ, Klubo-Gwiezdzinska J, Banga JP, Neumann S, Gershengorn MC.

Thyroid (2020 Feb) 30:270-276. Abstract/Full Text

Thyrotropin Causes Dose-dependent Biphasic Regulation of cAMP Production Mediated by G(s) and G(i/o) Proteins.

Neumann S, Malik SS, Marcus-Samuels B, Eliseeva E, Jang D, Klubo-Gwiezdzinska J, Krieger CC, Gershengorn MC.

Mol Pharmacol (2020 Jan) 97:2-8. Abstract/Full Text

Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk.

Krieger CC, Boutin A, Jang D, Morgan SJ, Banga JP, Kahaly GJ, Klubo-Gwiezdzinska J, Neumann S, Gershengorn MC.

Endocrinology (2019 Jun 1) 160:1468-1479. Abstract/Full Text

Thyroid Stimulating Hormone (TSH)/Insulin-like Growth Factor 1 (IGF1) Receptor Cross-talk in Human Cells.

Krieger CC, Morgan SJ, Neumann S, Gershengorn MC.

Curr Opin Endocr Metab Res (2018 Oct) 2:29-33. Abstract/Full Text

Evidence That Graves' Ophthalmopathy Immunoglobulins Do Not Directly Activate IGF-1 Receptors.

Marcus-Samuels B, Krieger CC, Boutin A, Kahaly GJ, Neumann S, Gershengorn MC.

Thyroid (2018 May) 28:650-655. Abstract/Full Text

Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro.

Neumann S, Eliseeva E, Boutin A, Barnaeva E, Ferrer M, Southall N, Kim D, Hu X, Morgan SJ, Marugan JJ, Gershengorn MC.

J Pharmacol Exp Ther (2018 Jan) 364:38-45. Abstract/Full Text

Normal Human Thyrocytes in Culture.

Morgan SJ, Neumann S, Gershengorn MC.

Methods Mol Biol (2018) 1817:1-7. Abstract/Full Text

TSHR/IGF-1R Cross-Talk, Not IGF-1R Stimulating Antibodies, Mediates Graves' Ophthalmopathy Pathogenesis.

Krieger CC, Neumann S, Marcus-Samuels B, Gershengorn MC.

Thyroid (2017 May) 27:746-747. Abstract/Full Text

Inhibiting thyrotropin/insulin-like growth factor 1 receptor crosstalk to treat Graves' ophthalmopathy: studies in orbital fibroblasts in vitro.

Place RF, Krieger CC, Neumann S, Gershengorn MC.

Br J Pharmacol (2017 Feb) 174:328-340. Abstract/Full Text

Thyrotropin Stimulates Differentiation Not Proliferation of Normal Human Thyrocytes in Culture.

Morgan SJ, Neumann S, Marcus-Samuels B, Gershengorn MC.

Front Endocrinol (Lausanne) (2016) 7:168. Abstract/Full Text

An Enantiomer of an Oral Small-Molecule TSH Receptor Agonist Exhibits Improved Pharmacologic Properties.

Neumann S, Padia U, Cullen MJ, Eliseeva E, Nir EA, Place RF, Morgan SJ, Gershengorn MC.

Front Endocrinol (Lausanne) (2016) 7:105. Abstract/Full Text

TSH/IGF-1 Receptor Cross Talk in Graves' Ophthalmopathy Pathogenesis.

Krieger CC, Place RF, Bevilacqua C, Marcus-Samuels B, Abel BS, Skarulis MC, Kahaly GJ, Neumann S, Gershengorn MC.

J Clin Endocrinol Metab (2016 Jun) 101:2340-7. Abstract/Full Text

Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells.

Boutin A, Neumann S, Gershengorn MC.

Endocrinology (2016 May) 157:2173-81. Abstract/Full Text

Future Prospects for the Treatment of Graves' Hyperthyroidism and Eye Disease.

Neumann S, Place RF, Krieger CC, Gershengorn MC.

Horm Metab Res (2015 Sep) 47:789-96. Abstract/Full Text

Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves' disease immunoglobins.

Krieger CC, Neumann S, Place RF, Marcus-Samuels B, Gershengorn MC.

J Clin Endocrinol Metab (2015 Mar) 100:1071-7. Abstract/Full Text

β-Arrestin-1 mediates thyrotropin-enhanced osteoblast differentiation.

Boutin A, Eliseeva E, Gershengorn MC, Neumann S.

FASEB J (2014 Aug) 28:3446-55. Abstract/Full Text

A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice.

Neumann S, Nir EA, Eliseeva E, Huang W, Marugan J, Xiao J, Dulcey AE, Gershengorn MC.

Endocrinology (2014 Jan) 155:310-4. Abstract/Full Text

Novel insights on thyroid-stimulating hormone receptor signal transduction.

Kleinau G, Neumann S, Grüters A, Krude H, Biebermann H.

Endocr Rev (2013 Oct) 34:691-724. Abstract/Full Text

A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy.

Turcu AF, Kumar S, Neumann S, Coenen M, Iyer S, Chiriboga P, Gershengorn MC, Bahn RS.

J Clin Endocrinol Metab (2013 May) 98:2153-9. Abstract/Full Text

Update in TSH receptor agonists and antagonists.

Gershengorn MC, Neumann S.

J Clin Endocrinol Metab (2012 Dec) 97:4287-92. Abstract/Full Text

Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.

Boutin A, Allen MD, Neumann S, Gershengorn MC.

FASEB J (2012 Aug) 26:3473-82. Abstract/Full Text

A drug-like antagonist inhibits thyrotropin receptor-mediated stimulation of cAMP production in Graves' orbital fibroblasts.

Neumann S, Pope A, Geras-Raaka E, Raaka BM, Bahn RS, Gershengorn MC.

Thyroid (2012 Aug) 22:839-43. Abstract/Full Text

Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling.

Allen MD, Neumann S, Gershengorn MC.

FASEB J (2011 Oct) 25:3687-94. Abstract/Full Text

Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling.

Boutin A, Allen MD, Geras-Raaka E, Huang W, Neumann S, Gershengorn MC.

Mol Pharmacol (2011 Aug) 80:240-6. Abstract/Full Text

Small-molecule thyrotropin receptor agonist activates naturally occurring thyrotropin-insensitive mutants and reveals their distinct cyclic adenosine monophosphate signal persistence.

Allen MD, Neumann S, Gershengorn MC.

Thyroid (2011 Aug) 21:907-12. Abstract/Full Text

Defining structural and functional dimensions of the extracellular thyrotropin receptor region.

Kleinau G, Mueller S, Jaeschke H, Grzesik P, Neumann S, Diehl A, Paschke R, Krause G.

J Biol Chem (2011 Jun 24) 286:22622-31. Abstract/Full Text

Small molecule TSHR agonists and antagonists.

Neumann S, Gershengorn MC.

Ann Endocrinol (Paris) (2011 Apr) 72:74-6. Abstract/Full Text

A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.

Neumann S, Eliseeva E, McCoy JG, Napolitano G, Giuliani C, Monaco F, Huang W, Gershengorn MC.

J Clin Endocrinol Metab (2011 Feb) 96:548-54. Abstract/Full Text

Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.

Haas AK, Kleinau G, Hoyer I, Neumann S, Furkert J, Rutz C, Schülein R, Gershengorn MC, Krause G.

Cell Mol Life Sci (2011 Jan) 68:159-67. Abstract/Full Text

Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization.

Neumann S, Geras-Raaka E, Marcus-Samuels B, Gershengorn MC.

FASEB J (2010 Oct) 24:3992-9. Abstract/Full Text

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.

Kleinau G, Haas AK, Neumann S, Worth CL, Hoyer I, Furkert J, Rutz C, Gershengorn MC, Schülein R, Krause G.

FASEB J (2010 Jul) 24:2347-54. Abstract/Full Text

A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.

Neumann S, Huang W, Eliseeva E, Titus S, Thomas CJ, Gershengorn MC.

Endocrinology (2010 Jul) 151:3454-9. Abstract/Full Text

Constitutively active thyrotropin and thyrotropin-releasing hormone receptors and their inverse agonists.

Neumann S, Raaka BM, Gershengorn MC.

Methods Enzymol (2010) 485:147-60. Abstract/Full Text

Human TSH receptor ligands as pharmacological probes with potential clinical application.

Neumann S, Raaka BM, Gershengorn MC.

Expert Rev Endocrinol Metab (2009 Nov 1) 4:669. Abstract/Full Text

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.

Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC.

Proc Natl Acad Sci U S A (2009 Jul 28) 106:12471-6. Abstract/Full Text

A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism.

Neumann S, Kleinau G, Costanzi S, Moore S, Jiang JK, Raaka BM, Thomas CJ, Krause G, Gershengorn MC.

Endocrinology (2008 Dec) 149:5945-50. Abstract/Full Text

A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists.

Engel S, Skoumbourdis AP, Childress J, Neumann S, Deschamps JR, Thomas CJ, Colson AO, Costanzi S, Gershengorn MC.

J Am Chem Soc (2008 Apr 16) 130:5115-23. Abstract/Full Text

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor.

Titus S, Neumann S, Zheng W, Southall N, Michael S, Klumpp C, Yasgar A, Shinn P, Thomas CJ, Inglese J, Gershengorn MC, Austin CP.

J Biomol Screen (2008 Feb) 13:120-7. Abstract/Full Text

Identification of residues important for agonist recognition and activation in GPR40.

Sum CS, Tikhonova IG, Neumann S, Engel S, Raaka BM, Costanzi S, Gershengorn MC.

J Biol Chem (2007 Oct 5) 282:29248-55. Abstract/Full Text

Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition.

Tikhonova IG, Sum CS, Neumann S, Thomas CJ, Raaka BM, Costanzi S, Gershengorn MC.

J Med Chem (2007 Jun 28) 50:2981-9. Abstract/Full Text

Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.

Moore S, Jaeschke H, Kleinau G, Neumann S, Costanzi S, Jiang JK, Childress J, Raaka BM, Colson A, Paschke R, Krause G, Thomas CJ, Gershengorn MC.

J Med Chem (2006 Jun 29) 49:3888-96. Abstract/Full Text

Low affinity analogs of thyrotropin-releasing hormone are super-agonists.

Engel S, Neumann S, Kaur N, Monga V, Jain R, Northup J, Gershengorn MC.

J Biol Chem (2006 May 12) 281:13103-13109. Abstract/Full Text

A novel activating mutation in transmembrane helix 6 of the thyrotropin receptor as cause of hereditary nonautoimmune hyperthyroidism.

Nwosu BU, Gourgiotis L, Gershengorn MC, Neumann S.

Thyroid (2006 May) 16:505-12. Abstract/Full Text

A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).

Jäschke H, Neumann S, Moore S, Thomas CJ, Colson AO, Costanzi S, Kleinau G, Jiang JK, Paschke R, Raaka BM, Krause G, Gershengorn MC.

J Biol Chem (2006 Apr 14) 281:9841-4. Abstract/Full Text

Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor.

Neumann S, Krause G, Claus M, Paschke R.

Endocrinology (2005 Jan) 146:477-85. Abstract/Full Text