Bile Acid-Mediated Integration of Metabolism and Liver Disease: A Research Workshop

Event Details

Meeting Objectives

Bile acids are arguably the perfect nutritional/metabolic integrator amphipathic cholesterol-derived molecules that solubilize diet-derived lipids in the intestine and signal through membrane and nuclear receptors to regulate whole body energy metabolism, intracellular signaling, and nuclear function. In various disease states, circulating bile acids drive normal and pathological processes in multiple organs both within and without enterohepatic tissues. This Workshop is designed to explore opportunities to define how drugs based on bile acid structure and activity can be utilized best to promote health. Disease targets include cholestasis, viral and autoimmune hepatitis, obesity/NASH, diabetes, and metabolism.

Planning Committee

• Saul Karpen
• James Boyer
• Keith Lindor
• David Moore
• Fred Suchy
• Edward Doo
• Jay Hoofnagle

Agenda

June 8, 2012

8:00 - 8:05 a.m.

Welcome and Introduction
Saul Karpen and Edward Doo

8:05 - 8:30 a.m.

Keynote Talk
Bile Acids: Lessons for Therapeutic Intent
Alan Hofmann

Session 1: Bile Acid Chemistry and Molecular Targets

James Boyer (Moderator)

8:30 - 8:50 a.m.

Bile Acids Linking Intestinal and Liver Physiology
Steve Kliewer

8:50 - 9:10 a.m.

Molecular Targets for Therapeutic Bile Acids
Ulrich Beuers

9:10 - 9:30 a.m.

TGR5
Kristina Schoonjans

9:30 - 9:50 a.m.

Inactivation of Basolateral Transporter Ostα-Ostβ Alters Bile Acid Homeostasis via the FXR-FGF15 Pathway
Tian Lan

9:50 - 10:10 a.m.

Discussion

10:10 - 10:30 a.m.

Break and Poster Viewing

Session 2: Liver Biology and Toxicity

Fred Suchy (Moderator)

10:30 - 10:50 a.m.

Bile Acid-mediated Toxicity and Multi-organ Adaptation to Cholestasis
Jim Boyer

10:50 - 11:10 a.m.

Co-regulator Regulation of Bile Acid Homeostasis in Health and Disease
Fred Suchy

11:10 - 11:30 a.m.

Intracellular Signaling Affected by Bile Acids
Sawket Anwer

11:30 - 11:50 a.m.

Bile Acids in Hepatocyte Signaling and Polarity
Irwin Arias

11:50 a.m. - 12:10 p.m.

Discussion

12:10 - 1:10 p.m.

Lunch and Poster Viewing

Session 3: Disease Models

Kristina Schoonjans (Moderator)

1:10 - 1:30 p.m.

Bile Acids and Liver Cancer
David Moore

1:30 - 1:50 p.m.

Sleeve Gastrectomy in Obese Mice Raises Serum Bile Acid Levels and Modulates the FXR-SREBP-1c Pathway to Reduce Hepatic Triglyceride Levels
Andriy Myronovych

1:50 - 2:10 p.m.

Serum MicroRNA: Novel Biomarkers for Prognosis of Ursodeoxycholic Acid Treatment in Primary Sclerosing Cholangitis
Yu Li

2:10 - 2:30 p.m.

Crosstalk Between Inflammation and Bile Acid Regulated Pathways in Liver
Saul Karpen

2:30 - 2:50 p.m.

Break and Poster Viewing

Session 4: Human Trials and Targets

Keith Lindor (Moderator)

2:50 - 3:10 p.m.

Ursodeoxycholic Acid (UDCA) and 6α Ethyl Chenodeoxycholic Acid (6αECDCA) for Cholangiopathies
Keith Lindor

3:10 - 3:30 p.m.

NorUDCA
Michael Trauner

3:30 - 3:50 p.m.

ECDCA for Nonalcoholic Steatohepatitis (NASH)
Arun Sanyal

3:50 - 4:10 p.m

TGR5: Genomics and Therapeutics
Verena Keitel

4:10 - 4:30 p.m.

Cholic Acid: From Discovery to Clinical PracticeM
Kenneth Setchell

Session 5: Interactive Discussion : Setting the Agenda

Edward Doo and Jay Hoofnagle (Moderators)

4:30 - 5:00 p.m

Edward Doo, Jay Hoofnagle, Saul Karpen, Kristina Schoonjans, Jim Boyer, Arun Sanyal, Keith Lindor, Fred Suchy, Michael Trauner

5:00 p.m.

Adjournment