Workshop on Human Milk Composition – Biological, Environmental, Nutritional, and Methodological Considerations

Event Details

Background

The Federal Data Consortium on Pregnancy and Birth to 24 Months (P/B24) is a forum of Federal agencies to discuss needs for data on P/B24 populations and find opportunities for collaborative initiatives. Through this Data Consortium, high priority needs were articulated for current and expanded data on the composition of human milk for advancing public health initiatives. The U.S. Department of Agriculture’s (USDA) Agricultural Research Service (ARS) has maintained the food composition data in the USDA National Nutrient Database for Standard Reference (SR), including for human milk. However, these data are not current and the published literature do not provide adequate data to update the SR database for human milk. As such, ARS is collaborating with the Office of Disease Prevention and Health Promotion (ODPHP) of the U.S. Department of Health and Human Services (HHS) and the sponsoring agency for this workshop, the Office of Nutrition Research of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) of HHS to first gather information 1) on the scientific needs for human milk composition (HMC) data, 2) on experimental designs for human milk collection, storage, and analysis, and 3) to develop a vision for establishing a research program to develop a HMC Database.

The focus of participation in this meeting is for Federal agencies with scientific expertise and/or interest in the composition of human milk. Non-federal participants include invited academic experts in human milk composition and experimental designs for human milk collection, storage, and analysis as well as database development. The role of non-federal invited experts is to assist the federal agencies in information gathering. As such, invited presentations should address the state of the science on the topic, which should be informed by personal research experiences, but not present the individual’s research program or study results.

The information presented through this meeting, including the list of attendees, will be published in a peer-reviewed journal. All attendees will be asked to provide appropriate disclosures.

Meeting Objectives

Through presentations, open discussion, and follow-up communications this workshop aims to

• Present and discuss the scientific needs for data on human milk composition
• Explore the current understanding of factors affecting milk composition and identify methodological challenges in human milk collection, storage, and analysis
• Develop a vision to establish a research program to develop a human milk composition database

Organizing Committee

Office of Nutrition Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U.S. Department of Health and Human Services

Christopher Lynch, Ph.D. (POC: christopher.lynch@nih.gov)

Office of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services

Richard Olson, M.D., M.P.H.
Kellie Casavale, Ph.D., R.D. (POC: kellie.casavale@hhs.gov)

Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service U.S. Department of Agriculture

Pamela Pehrsson, Ph.D.
Xianli Wu, Ph.D.
Jaspreet Ahuja, M.S. (POC: jaspreet.ahuja@ars.usda.gov)

Registration Deadline

Please register to attend this workshop by October 25th, 2017, indicating whether you prefer to attend in-person or by webinar.

Non-federal attendance is by invitation only. Federal in-person attendance is space-limited. Priority will be given to individuals on the “Volunteer Interest/Expert Group” that includes staff from Federal agencies with scientific expertise and/or interest in the composition of human milk and academic experts in experimental designs for human milk collection, storage, and analysis as well as database development. For those who register to attend in-person, if space is not available, you will be contacted after registration closes and provided the webinar instruction.

Agenda

November 16, 2017

9:00 a.m. – 9:15 a.m.

Welcome from the Directors of the NIH Office of Nutrition Research and the USDA Human Nutrition Research Center
Christopher J. Lynch, Ph.D.
Director, Office of Nutrition Research
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institutes of Health, HHS

Naomi K. Fukagawa, M.D., Ph.D.
Director, Beltsville Human Nutrition Research Center (BHNRC)
Agricultural Research Center (ARS), USDA

9:15 a.m. – 9:25 a.m.

Review of Agenda and Introduction of Speakers
Kellie O. Casavale, Ph.D., R.D.
Nutrition Advisor, Office of Disease Prevention and Health Promotion (ODPHP)
Office of the Assistant Secretary for Health (OASH), HHS

Session 1: Scientific Needs for Data on Human Milk

9:25 a.m. – 9:45 a.m.

Perspectives from Federal Agencies
Kellie O. Casavale, Ph.D., R.D.
ODPHP, OASH, HHS

9:45 a.m. – 10:05 a.m.

Perspectives from Non-federal Academic Researchers
Shelley McGuire, Ph.D.
Washington State University

10:05 a.m. – 11:05 a.m.

Panel Discussion and Q/A with Attendees
Co-moderators: Pamela Pehrsson, Ph.D., Beltsville HNRC, ARS, USDA
Kellie O. Casavale, Ph.D., R.D., ODPHP, OASH, HHS

Panelists
Doug Balentine, Ph.D.
Food and Drug Administration

Mandy Brown Belfort, M.D., M.P.H.
Brigham and Women’s Hospital, Harvard Medical School

Bruce German, Ph.D.
University of California, Davis

Deborah Hayward, B.Sc. Hons, PG Dip
Health Canada
(participating remotely)

Erin Hines, Ph.D., D.A.B.T.
Environmental Protection Agency

James McClung, Ph.D.
Department of Defense
(participating remotely)

Shelley McGuire, Ph.D.
Washington State University

Cria Perrine, Ph.D.
Centers for Disease Control and Prevention

Catherine Spong, M.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Kathleen Rasmussen, Sc.D.
Cornell University

11:05 a.m. – 11:20 a.m.

Break

11:20 a.m. – 11:30 a.m.

Greetings from the Deputy Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Catherine Y. Spong, M.D.
Deputy Director, NICHD, NIH, HHS

Session 2: Influential Factors on Human Milk Composition

11:30 a.m. – 11:50 a.m.

Biology of Lactation and Human Milk (presenting remotely)
Margaret (Peggy) Neville, Ph.D., University of Colorado, Denver (Professor Emerita)

11:50 a.m. – 12:10 p.m.

Lactation and Milk: The Roughs and the Smooths, Milk’s Constant and Dynamic Dimensions
Bruce German, Ph.D., University of California, Davis

12:10 p.m. – 12:30 p.m.

Milk Proteins and Peptides: Bioactivity, Characterization, and Quantification
David Dallas, Ph.D., Oregon State University

12:30 p.m. – 12:50 p.m.

Micronutrients in Human Milk: Implications for Recommended Intakes and Study Design
Lindsay H. Allen, Ph.D., USDA ARS Western Human Nutrition Research Center, University of California, Davis

12:50 p.m. – 1:50 p.m.

Lunch Break

Session 2, Continued: Influential Factors on Human Milk Composition

Components of Human Milk (continued)

1:50 p.m. – 2:10 p.m.

Milk’s Non-Nutritive Components and Microbiome in Brief
Shelley McGuire, Ph.D., Washington State University

2:10 p.m. – 2:30 p.m.

Milk Exosomes and RNA Cargos
Janos Zempleni, Ph.D., University of Nebraska-Lincoln

2:30 p.m. – 2:50 p.m.

Panel Discussion and Q/A with Attendees
Moderator: Jaspreet Ahuja, M.S., ARS, USDA

2:50 p.m. – 3:05 p.m.

Break

3:05 p.m. – 3:25 p.m.

Considerations of Time Intervals, Timing, and Time Frame in Sampling Human Milk
Laurie Nommsen-Rivers, Ph.D., R.D., IBCLC, University of Cincinnati

3:25 p.m. – 3:45 p.m.

Variation in Human Milk Composition: Maternal Factors
Ardythe Morrow, Ph.D., M.Sc., University of Cincinnati Children's Hospital Medical Center

3:45 p.m. – 4:05 p.m.

Factors that Affect Milk Composition: Maternal Diet
Kathleen Rasmussen, Sc.D., Cornell University

4:05 p.m. – 4:25 p.m.

Environmental Chemicals in Breast Milk and Formula
Erin Hines, National Center for Environmental Assessment, EPA

4:25 p.m. – 4:45 p.m.

Panel Discussion and Q/A with Attendees
Moderator: Jaspreet Ahuja, M.S., ARS, USDA

4:45 p.m.

Adjourn

November 17, 2017

8:30 a.m. – 8:40 a.m.

Greetings from the Deputy Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Gregory G. Germino, M.D.
Deputy Director, NIDDK, HHS

8:40 a.m. – 8:50 a.m.

Review of Agenda and Introduction of Speakers
Kellie O. Casavale, Ph.D., R.D., ODPHP, OASH, HHS

Session 3: Considerations for Data Quality

Sampling Strategies

8:50 a.m. – 9:10 a.m.

Population-Based Sampling: Practice and Considerations
Amy Branum, Ph.D., M.S.P.H., NCHS, CDC, HHS

9:10 a.m. – 9:30 a.m.

Practical Considerations in Sampling Human Milk Composition and Breast Milk Intake Volumes in the U.S.
Laurie Nommsen-Rivers, Ph.D., R.D., IBCLC, University of Cincinnati

9:30 a.m. – 9:45 a.m.

Effects of Sampling, Sample Handling, and Analysis on Human Milk Composition Data: Retrospective View
Xianli Wu, Ph.D., C.F.S., ARS, USDA

9:45 a.m. – 10:00 a.m.

Considerations and Complexities in Standardizing Milk Collection and Storage: Focus on Micronutrients
Lindsay H. Allen, Ph.D., USDA ARS Western Human Nutrition Research Center, University of California, Davis

10:00 a.m. – 10:15 a.m.

Considerations and Complexities in Standardizing Milk Collection, Storage, and Analysis: Milk Lipids and Microbiome
Mark McGuire, Ph.D., University of Idaho

10:15 a.m. – 10:30 a.m.

Considerations of Human Milk Analysis with Respect to Macronutrient Properties, Donor Milk Processing, and Milk Thickening
Jae Kim, M.D., Ph.D., University of California, San Diego

10:30 a.m. – 10:50 a.m.

Panel Discussion and Q/A with Attendees
Moderator: Xianli Wu, Ph.D., C.F.S., ARS, USDA

10:50 a.m. – 11:10 a.m.

Break

Session 4: Developing a Vision to Establish a Research Program for Human Milk Composition

11:10 a.m. – 11:25 a.m.

Best Practices for Human Milk Content Measurements, Analysis, and Databasing
Shankar Subramaniam, Ph.D., University of California, San Diego

11:25 a.m. – 11:40 a.m.

Human Milk in the Internet of Food: How, What, When, Where, Why
Matthew Lange, Ph.D., University of California, Davis

Sharing Visions

11:40 a.m. – 11:55 a.m.

Overview of the ECHO Program
Manjit Hanspal, Ph.D., ECHO Project, NIH, HHS

11:55 a.m. – 12:10 p.m.

Nutrient Data Laboratory's Vision for the Human Milk Composition Database
Jaspreet Ahuja, M.S., ARS, USDA

12:10 p.m. – 12:25 a.m.

A Vision for the Human Milk Composition Database of the United States and Canada
Ardythe Morrow, Ph.D., M.Sc., University of Cincinnati Children's Hospital Medical Center

12:25 p.m. – 12:40 p.m.

Human Milk and Nutrition Research at NIH
Christopher J. Lynch, Ph.D., ONR, NIDDK, NIH, HHS

12:40 p.m. – 1:00 p.m.

Panel Discussion and Q/A and Visions from Attendees
Moderator: Pamela Pehrsson, Ph.D., Beltsville HNRC, ARS, USDA

1:00 p.m. – 1:15 p.m.

Next Steps for Development of a Research Program Proposal
Pamela Pehrsson, Ph.D., Beltsville HNRC, ARS, USDA

1:15 p.m.

Adjourn