Hematopoietic Response to Stress

Event Details

Background

With the advent of single cell analyses, the classical hierarchical model of hematopoiesis is being challenged. Recent models predict that Hematopoietic Stem Cells (HSCs) are heterogeneous and that a subset is selectively favored to respond to environmental stress conditions by rapid proliferation. The purpose of the workshop is to explore data for the identity of such a “stress-response” cell and to examine how these cells invoke different pathways from normal hematopoiesis. The molecular bases of these responses are emerging as variations on themes such as the maintenance of the integrity of the genome, post-transcriptional regulation of gene expression, changes in epitranscriptomics, alterations in subcellular organelles, and management of reactive oxygen species. This workshop aims to review the most recent progress in the field and to promote discussion of the gaps in our knowledge of these biological processes and pathways. We also expect to gain a specific understanding of the current scientific and technologic barriers to the hematology research community in the pursuit of knowledge in this area.

Meeting Objectives

This conference supports the mission to disseminate science-based information on hematologic diseases by inviting leaders investigating the impact of stress on hematopoiesis to share their latest research findings with the research community. This conference supports the goal to maintain a vigorous investigator-initiated research portfolio by allowing the opportunity for investigators to articulate specific research needs and by providing an opportunity for commentary by the community.

Registration Deadline

April 28, 2019

Agenda

April 29, 2019

8:00 – 8:30 a.m.

Registration and poster setup

8:30 a.m.

Welcome and opening remarks
Griffin P. Rodgers, M.D., MACP, Director, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH
W. Keith Hoots, M.D., Director, Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, NIH
Felipe Sierra, Ph.D., Director, Division of Aging Biology, National Institute on Aging, NIH

8:45 a.m.

Introductions and goals of the workshop
Terry Bishop, Ph.D., NIDDK, NIH

Keynote/Introduction

9:00 – 9:30 a.m.

Hematopoietic Response to Stress, a Necessity of Life
Emmanuelle Passegué, Ph.D., Columbia University

Session 1: Hematopoietic Stem Cell (HSC) Heterogeneity

9:30 – 10:00 a.m.

HSC Heterogeneity from the Single-cell Viewpoint
Nina Cabezas Wallscheid, Ph.D., Max Planck Institute of Immunobiology and Epigenetics

10:00 – 10:30 a.m.

Discrete Hematopoietic Cell States
H. Leighton Grimes, Ph.D., Cincinnati Children’s Hospital Medical Center

10:30 – 11:00 a.m.

HSC Heterogeneity by Single-cell Analysis
Fernando Camargo, Ph.D., Boston Children’s Hospital

11:00 – 11:15 a.m.

Break

Session 2: Stress Response Mechanisms

11:15 – 11:45 a.m.

Pleiotrophin Secretion Regulates HSC Maintenance and Regeneration
John Chute, M.D., University of California, Los Angeles

11:45 a.m. – 12:15 p.m.

Stress Induced by DNA Repair Deficiency (in Mice)
Laura Niedernhofer, M.D., Ph.D., University of Minnesota

12:15 – 12:45 p.m.

Protection against DNA Replication Stress in Hematopoiesis
Christine Eischen, Ph.D., Thomas Jefferson University

12:45 – 2:45 p.m.

Lunch and poster presentations

2:45 – 3:15 p.m.

RNA Methylation Affects HSC Expansion
Chuan He, Ph.D., The University of Chicago

3:15 – 3:45 p.m.

RNA Modification in Hematopoiesis
Jianjun Chen, Ph.D., Beckman Research Institute, City of Hope

Session 3: Inflammation and Regeneration

3:45 – 4:15 p.m.

Chronic Inflammation as a Regulator of HSC Function and Fitness
Eric Pietras, Ph.D., University of Colorado Anschutz Medical Campus

4:15 – 4:45 p.m.

Heterogeneous Responses of HSCs to Inflammatory Stimuli Are Altered with Age
Mati Mann, Ph.D., California Institute of Technology

4:45 – 5:15 p.m.

Granulocyte-derived TNFa in HSC Regeneration
Daniel Lucas, Ph.D., Cincinnati Children’s Hospital Medical Center

Tuesday, April 30, 2019

Session 4: Metabolic Response and Aging

8:00 – 8:30 a.m.

Stress Impact on Mitochondrial Function
Marie-Dominique Filippi, Ph.D., Cincinnati Children’s Hospital Medical Center

8:30 – 9:00 a.m.

Hematopoietic Response to Infection
Katherine King, M.D., Ph.D., Baylor College of Medicine

9:00 – 9:30 a.m.

Mitochondrial Metabolic Checkpoint, Hematopoietic Stem Cell Aging and Rejuvenation
Danica Chen, Ph.D., University of California, Berkeley

9:30 – 10:00 a.m.

Mitofission 2 Fusing Mitochondria and Change with Age
Hans-Willem Snoeck, M.D., Ph.D., Columbia University Irving Medical Center

10:00 – 10:15 a.m.

Break

10:15 – 10:45 a.m.

Metabolic Stress and Asymmetric Division
Keisuki Ito, M.D., Ph.D., Albert Einstein College of Medicine

10:45 – 11:15 a.m.

The Regulation of Proteostasis in HSCs
Robert Signer, Ph.D., University of California, San Diego

11:15 – 11:45 a.m.

Iron Metabolism and HSC Functions
Britta Will, Ph.D., Albert Einstein College of Medicine

11:45 a.m. – 12:30 p.m.

Identification of Gaps in Knowledge: Summary
Moderators: Emmanuelle Passegué, Ph.D. and Marie-Dominique Filippi, Ph.D.
With audience participation

12:30 p.m.

Adjournment

Abstracts

Abstracts are invited for poster presentations. The poster session will be held in the Atrium. Space is limited, and the organizing committee may implement a selection process a breadth of meritorious research is presented.

Submission Deadline

April 1, 2019

Submitting Abstracts

All abstracts must be submitted via email to Danielle Johnikin of The Scientific Consulting Group, Inc. at djohnikin@scgcorp.com with Hematopoietic Stress in the subject line.
Download the Abstract Template (DOCX, 24.16 KB)
Selected abstracts will be presented in poster form.

Junior level participants (students, fellows, instructors and assistant professors) with the highest scoring abstracts will be eligible for a modest travel award.

Abstract selections and travel award notifications will be made the week of April 22, 2019.

Formatting Requirements

Please follow the instructions below to format an abstract. (Note: Submissions will not be edited for spelling or grammar and will be accepted “as is.”)

• A completed poster abstract should include a statement of purpose, methods used, and a summary of results in sufficient detail to support the conclusion. Statements such as “results will be described” should be avoided.
• The poster abstract should fit on half of an 8.5” × 11” page. Abstracts should be no longer than 250 words (not including name and affiliation).
• The abstract should be typed single-spaced using 12-point Times New Roman font.
• The title should be boldface and followed by one return.
• The author list (authors’ first and last names, degrees) with institutions listed in a separate paragraph—including city, state, and country—should be followed by one return. The name of the presenting author should be underlined. Provide any grant acknowledgments for your research (e.g., R01-DK13028) at the end of your abstract.
• The abstract file should be saved as: presenting author’s Last name_First word in the title (e.g., Zucker_Effects).

Poster Presentations

Selected poster abstracts will appear in the meeting materials. Each author is allotted a 4-foot-high by 6-foot-wide poster board. The poster session will be held during the lunch break.

If your abstract is selected for a poster presentation, please arrive between 8:00 and 8:30 a.m., April 29, 2019, to mount your poster on the posterboard. Pushpins and Velcro will be provided onsite. You will be responsible for removing and shipping your poster at the end of the meeting. Any remaining posters will be discarded.

If you have any questions about the scientific content of the workshop, please contact Dr. Cindy Roy. For questions/concerns about workshop logistics, please contact Ms. Danielle Johnikin. We look forward to meeting and working with you. We anticipate a stimulating and productive workshop.

Photography Guidelines

Photography is not allowed where posters are displayed.