Imaging the Pancreas in Diabetes, and Benign and Malignant Exocrine Pancreatic Disease

Event Details

You may also be interested in the Strategies for Clinical Imaging in Diabetes meeting.

Background

There are a large number of questions that are arising from clinical experience in the exocrine pancreas field that impact issues of diabetes pathogenesis, and vice versa—the observation of substantial changes in exocrine size and likely architecture that precede diabetes onset is one striking example of this. Other examples include inflammation and changes in organ blood flow, and the incidence of diabetes (both T1D and T2D) with exocrine diseases of various sorts. Treatment of a disease with an endocrine or exocrine pathogenesis can affect the function (good and bad) of the entire pancreas. It has become clear that while the endocrine and exocrine pancreas are studied by different communities, and the diseases are treated by people in different medical disciplines, there is a great deal to be learned at the intersection. Imaging of the pancreas is at that intersection. Many of the goals for imaging in the pancreas are similar for endocrinologists and pancreatologists, and include size, architecture and tissue physical properties such as stiffness, vasculature, nerves, inflammation, fibrosis and fat deposition. Even imaging goals specific to different disciplines, such as the goals to image islet and beta cell mass and function or to visualize tumors, can yield information that is likely to inform both communities of scientists and clinicians.

Objectives

The goal of this symposium is to showcase the use of imaging in the pancreas to detect and explore the pathogenesis of diabetes, pancreatic cancers, pancreatitis and other pancreatic diseases, in humans and model systems. The emphasis is on observations and biology from the fields of diabetes and pancreas disease research that can potentially inform each other.

Organizing Committee

Gary Cline, Yale University
Martin Gotthardt, Radboud University Nijmegen, Netherlands
Paul E. Harris, Columbia University
Anna Moore, Michigan State University
Alvin Powers, Vanderbilt University
Dana Anderson, NIDDK, NIH
Olivier Blondel, NIDDK, NIH
Maren R. Laughlin, NIDDK, NIH
Lalitha Shankar, NCI, NIH

Registration Deadline

January 5, 2020

Agenda

You may also be interested in the Strategies for Clinical Imaging in Diabetes meeting.

January 13, 2020

Welcome and Workshop Overview and Goals

8:00 a.m. – 8:15 a.m.

Welcome
Griffin P. Rodgers, M.D., M.A.C.P., Director, NIDDK

8:15 a.m. – 8:30 a.m.

The State of the Art of Pancreas Imaging in Diabetes and Pancreatic Disease
Maren Laughlin, Ph.D., NIDDK

Keynote Talks: Introduction to the Pancreas and its Diseases

8:30 a.m. – 9:00 a.m.

Physiology, Cellular and Molecular Biology of the Exocrine Pancreas and its Disease Processes
Seung Kim, M.D., Ph.D., Stanford University

9:00 a.m. – 9:30 a.m.

Links Between Diabetes, and Benign and Malignant Pancreatic Diseases, Including Surgical Outcomes
Stephen Pandol, M.D., Cedars-Sinai Medical Center

9:30 a.m. – 9:50 a.m.

Break

Session One: Clinical Imaging for Benign and Malignant Pancreatic Disease

9:50 a.m. – 10:10 a.m.

Clinical MRI in Pancreatic Disease
Frank Miller, M.D., Northwestern University

10:10 a.m. – 10:30 a.m.

Detection of Pancreatic Exocrine Tumors
Elliot Fishman, M.D., Johns Hopkins Medicine

10:30 a.m. – 10:50 a.m.

Abstract Presentation Physiologic Pancreatic Cancer Imaging Using Dynamic Contrast-enhanced MRI (DCE-MRI)
Erin Gilbert, M.D., M.C.R., FACS, Oregon Health & Science University

10:50 a.m. – 11:10 a.m.

Molecular Imaging of Pancreatic Exocrine Tumors
Kimberly Kelly, Ph.D., University of Virginia

11:10 a.m. – 11:30 a.m.

Abstract Presentation Prediction of Pancreatic Ductal Adenocarcinoma Using Radiomic Analysis of CT Pancreatic Images
Touseef Ahmad Qureshi, Cedars-Sinai Medical Center

11:30 a.m. – 11:50 p.m.

Magnetic Resonance Active Transmembrane Water Cycling Detection of Early Adenocarcinoma
Charles Springer, Ph.D., Oregon Health & Science University

11:50 a.m. – 12:10 p.m.

Panel Discussion

12:10 p.m. – 1:10 p.m.

Lunch and Posters

Session Two: Imaging Pancreatic Physiology in Health and Disease

1:10 p.m. – 1:30 p.m.

Pancreas Size as a Biomarker for Diabetes Prediction and Progression
Jack Virostko, Ph.D., University of Texas at Austin

1:30 p.m. – 1:50 p.m.

Understanding Endocrine and Exocrine Pancreas Loss in Type-1 Diabetes
Martha Campbell-Thompson, Ph.D., D.V.M., University of Florida

1:50 p.m. – 2:10 p.m.

Imaging Inflammation in Pancreatitis
Aida Habtezion, M.D., M.Sc., Stanford University

2:10 p.m. – 2:30 p.m.

Pancreatic Stiffness in Pancreatitis (Elastography)
Andrew Trout, M.D., University of Cincinnati

2:30 p.m. – 2:50 p.m.

Break

2:50 p.m. – 3:10 p.m.

MRI of Pancreatic Fat and Fibrosis
Temel Tirkes, M.D., Indiana University

3:10 p.m. – 3:30 p.m.

Islet Amyloid Polypeptide (IAPP) Detection in Type 2 Diabetes Mellitus
Jonathan Wall, Ph.D., The University of Tennessee Medical Center

3:30 p.m. – 4:30 p.m.

Panel Discussion—Keynote, Session 1 and 2 Speakers and Moderators
Are Size, Fat, Inflammation, IAPP or Other Imageable Features of the Exocrine Pancreas Good Biomarkers for Prediction and Progression of Diabetes, Pancreatic Diseases or Cancer? Are Current Technologies Sufficient to Inform the Mechanism of the Disease Process?

4:30 p.m. – 5:30 p.m.

Poster Reception in Atrium

5:30 p.m.

Adjournment

January 14, 2020

Keynote Talks: Emerging Picture of Type 1 (T1D) and Type 2 Diabetes (T2D) Natural History

8:00 a.m. – 8:30 a.m.

The Endocrine Pancreas in T1D and T2D: Current Understanding
Mark Atkinson, Ph.D., University of Florida

8:30 a.m. – 9:00 a.m.

Inflammation, Diabetes and Pancreatic Disease, Checkpoint Inhibitor, Plasticity
Kevan Herold, M.D., Yale University

Session Three: Islet Architecture, Development, Differentiation

9:00 a.m. – 9:20 a.m.

Imaging Mass Cytometry in T1D/Immune and Islet Interactions
Klaus Kaestner, Ph.D., University of Pennsylvania

9:20 a.m. – 9:40 a.m.

Optical Quantitative 3-D Imaging of the Pancreas
Ulf Ahlgren, Ph.D., Umeå University, Sweden

9:40 a.m. – 10:00 a.m.

Break

10:00 a.m. – 10:20 a.m.

Cell-cell Communication—Channels in Islet Cell Interactions
Richard Benninger, Ph.D., University of Colorado

10:20 a.m. – 10:40 a.m.

Cell-cell communication—Omics to Find Pacemaker Cells
Guy Rutter, Imperial College London, United Kingdom

10:40 a.m. – 11:00 a.m.

Panel Discussion

Session Four: Islet Physiology—Nerves and Vessels

11:00 a.m. – 11:20 a.m.

Imaging Islet Neurobiology
Alessandro Caicedo, Ph.D., University of Miami

11:20 a.m. – 11:40 a.m.

Blood Flow in the Pancreas and Islet
Marcela Brissova, Ph.D., Vanderbilt University

11:40 a.m. – 12:00 p.m.

Pancreas Blood Flow as a Biomarker for Islet Function in People with Diabetes
Olof Eriksson, Ph.D., M.Sc., University of Uppsala, Sweden

12:00 p.m. – 12:20 p.m.

Abstract Presentation Integrated Pancreatic Microcirculation: Bi-directional Blood Flow between Endocrine and Exocrine Pancreas
Bryce Hendren-Santiago, University of Chicago

12:20 p.m. – 12:35 p.m.

Panel Discussion

12:35 p.m. – 1:30 p.m.

Lunch and Posters

Session Five: Molecular and Functional Imaging of the Islet

1:30 p.m. – 1:50 p.m.

Beta Cell Mass Imaging
Gary Cline, Ph.D., Yale University
Paul Harris, Ph.D., Columbia University

1:50 p.m. – 2:10 p.m.

Imaging Beta Cell Mass and Endocrine Tumors with Exenatide Agents
Marti Boss, M.Sc., Nijmegen University, The Netherlands

2:10 p.m. – 2:30 p.m.

Abstract Presentation Imaging Human Beta Cells with New RNA Aptamers Against Transmembrane p24 Trafficking Protein-6 and Clustering
Paolo Serafini, Ph.D., University of Miami

2:30 p.m. – 3:00 p.m.

Data-driven Discussion: Can We Visualize Beta Cell Function?
Discussants: Dean Sherry, Ph.D., The University of Texas Southwestern Medical Center
Weibo Cai, Ph.D., University of Wisconsin–Madison
Martin Gotthardt, M.D., Ph.D., Nijmegen University, The Netherlands
Paul Harris, Ph.D., Columbia University

3:00 p.m. – 3:20 p.m.

Imaging the Immune System in Diabetes
Olle Korsgren, M.D., Ph.D., University of Uppsala, Sweden

3:20 p.m. – 3:40 p.m.

Diabetes Theranostics for Native and Transplanted Islets
Anna Moore, Ph.D., Michigan State University

3:40 p.m. – 4:00 p.m.

Panel Discussion

4:00 p.m.

Adjournment

Abstracts

Submission Deadline

December 13, 2019

Submitting Abstracts

All abstracts must be submitted via email to Maren Laughlin and Gizem Fern.

Abstracts submissions are welcome which describe previously unpublished and unpresented work related to the mission and scope of the workshop. The work of selected abstracts will be presented in poster session, with a limited number invited to provide oral presentations during the workshop. Selected abstracts will be included in the program folder. Posters will be displayed on 4 x 6 ft poster boards.

Formatting Requirements

Please follow the instructions below to format an abstract.

The abstract should be a SINGLE PAGE MS Word document typed single-spaced using Times New Roman font. Use 0.5 inch margins at top and bottom of the page and 1.0 inch margins on the sides. Everything but the title should be in normal, 12-point font.

• The abstract’s title should be Bold, 16-Point, Title Case font and should clearly represent the nature of the investigation.
• On the line after the title, list the author’s first and last names, degree, affiliation, city, state, and country.
• Separate multiple authors with a semicolon; and underline the primary author’s name (one primary author per abstract).
• Skip one (blank) line between the title and the body of the abstract.
• Include (and label) sections on INTRODUCTION, METHODS, RESULTS, and CONCLUSIONS but do not use separate paragraphs for these sections.
• The abstract file name should follow this format: Last Name of primary author_First Word of Title (e.g., Zucker_Effects).
• Use of standard abbreviations is desirable (e.g., BMI), as well as standard symbols for units of measure (e.g., kg, g, mg, mL, L, and %). Place any special or unusual abbreviations in parentheses after the full word the first time that it appears. Use numerals to indicate numbers except to begin sentences. Do not use subheadings (e.g., Methods, Results).
• Simple tables, representative figures or graphs may be included; however, they must fit within the designated abstract space of one page.