Neurodegenerative Disorders and the Gut-Brain Axis: Parkinson's Disease

Event Details

Background

Each year approximately 60,000 Americans are diagnosed with Parkinson's disease and by 2030, nearly one million people in the U.S. will be living with the disease. Parkinson's disease symptoms are not limited to motor dysfunction and patients who develop Parkinson's disease often have a history of gastrointestinal (GI) symptoms, which may occur decades before the appearance of motor symptoms. There is a need for research on the neuropathological events in the GI tract that may provide insights into the disease origins and mechanisms associated with progressive neurodegeneration with the goal of developing innovative early-phase diagnostic tools or preventative therapies.

Objectives

1. Address issues in the coordinated care of motor symptoms as well as the non-motor GI dysfunction in patients with Parkinson’s disease.
2. Evaluate gut-brain communication in neurodegenerative disorders with a consideration of common mechanisms and approaches that may have cross-cutting impact for a broad range of neurodegenerative diseases.
3. Address gaps in knowledge of changes in enteric sensory processes and enteric nervous system structure and function in Parkinson’s disease.
4. Address the potential of the gastrointestinal tract as a source of biomarkers and novel therapeutic targets for early disease.
5. Facilitate crosstalk among brain-gut investigators from NIDDK, NINDS, and NIEHS (program officers from these institutes are on the organizing committee) and partnerships opportunities with these institutes for brain-gut research.

Organizing Committee

John Wiley, M.D., University of Michigan, co-chair
Gary Mawe, Ph.D., University of Vermont, co-chair
Kirsteen Browning, Ph.D., The Pennsylvania State University College of Medicine
Fredric Manfredsson, Ph.D., Barrow Neurological Institute

Terez Shea-Donohue, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Frank Hamilton, M.D., NIDDK
Patricia Greenwel, Ph.D., NIDDK
Beth-Anne Sieber, Ph.D., National Institute of Neurological Disorders and Stroke (NINDS)
Jonathan Hollander, Ph.D., National Institute of Environmental Health Sciences (NIEHS)

Lewis Morris, private citizen, Takoma Park, MD

Registration Deadline

September 28, 2021

Agenda

Thursday, September 30, 2021

10:00 a.m. – 10:10 a.m.

Welcoming Remarks
Stephen James, M.D., Director, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

10:10 a.m. – 10:30 a.m.

Introduction and Workshop Goals
Terez Shea-Donohue, Ph.D., Program Officer, NIDDK
NIDDK, NINDS, NIEHS Program Officers

SESSION 1—KEYNOTE TOPICS
Moderator: John Wiley, M.D., University of Michigan

10:30 a.m. – 11:00 a.m.

Parkinson’s Disease “Overview”
Anthony Lang, M.D., Krembil Research Institute, University of Toronto

11:00 a.m. – 11:30 a.m.

Environmental Triggers in Parkinson’s Disease
J. Timothy Greenamyre, M.D., Ph.D., Pittsburgh Institute for Neurodegenerative Diseases

11:30 a.m. – 12:00 p.m.

Parkinson’s Disease—Gastrointestinal (GI) Perspective
Michael Camilleri, M.D., Mayo Clinic

12:00 p.m. – 12:30 p.m.

Enteric Nervous System–Autonomic Nervous System Overview
Jim Galligan, Ph.D., Michigan State University

12:30 p.m. – 12:45 p.m.

Break

SESSION 2—GUT-BRAIN COMMUNICATION IN PARKINSON’S DISEASE
Moderator: Laura Volpicelli-Daley, Ph.D., The University of Alabama

12:45 p.m. – 1:10 p.m.

The Vagal Highway in Parkinson’s Disease
Kirsteen Browning, Ph.D., The Pennsylvania State College of Medicine

1:10 p.m. – 1:35 p.m.

Alpha Synuclein in the Central Nervous System and Enteric Nervous System
Jeffrey Kordower, Ph.D., Rush University

1:35 p.m. – 2:00 p.m.

Peripheral and Central Neuroinflammation in Parkinson’s Disease
Malú Tansey, Ph.D., University of Florida

2:00 p.m. – 2:30 p.m.

Question and Answer Panel

2:30 p.m. – 2:45 p.m.

Break

SESSION 3—ENTERIC NERVOUS SYSTEM IN PARKINSON’S DISEASE
Moderator: Gary Mawe, Ph.D., University of Vermont

2:45 p.m. – 3:10 p.m.

Neurodegeneration and Neurogenesis in the Enteric Nervous System
Faranak Fattahi, Ph.D., University of California, San Francisco

3:10 p.m. – 3:35 p.m.

Aging and the Enteric Nervous System
Meenakshi Rao, M.D., Ph.D., Boston Children’s Hospital

3:35 p.m. – 4:00 p.m.

The Enteric Nervous System in Parkinson’s Disease
Fredric Manfredsson, Ph.D., Barrow Neurological Institute

4:00 p.m. – 4:30 p.m.

Molecular Signatures of Parkinson’s Disease in the Gut
Bryan Killinger, Ph.D., Rush University Medical Center

4:30 p.m. – 5:00 p.m.

Question and Answer Panel

5:00 p.m.

Closing Remarks and Recess
Frank Hamilton, M.D., Program Officer, NIDDK

Friday, October 1, 2021

10:00 a.m. – 10:05 a.m.

Opening Remarks and Goals for Day 2
Patricia Greenwel, Ph.D., Program Officer, NIDDK

SESSION 4—SENSORY FUNCTION IN PARKINSON’S DISEASE
Moderator: Rodger Liddle, M.D., Duke University

10:05 a.m. – 10:30 a.m.

Enteroendocrine Cells and Parkinson’s Disease
Arthur Beyder, M.D., Ph.D., Mayo Clinic

10:30 a.m. – 10:55 a.m.

Enteric Glia Cells and Parkinson’s Disease
Brian Gulbransen, Ph.D., Michigan State University

10:55 a.m. – 11:20 a.m.

Enteric Nervous System Neuropathy and Parkinson’s Disease
Shanthi Srinivasan, M.D., Emory University

11:20 a.m. – 11:50 a.m.

Question and Answer Panel

11:50 a.m. – 12:00 p.m.

Break

SESSION 5—EVOLVING TARGETS AND THERAPIES
Moderator: Eamonn Quigley, M.D., Houston Methodist

12:00 p.m. – 12:30 p.m.

The Role of Barrier Function in Gut-Brain Communication
Ali Keshavarzian, M.D., Rush University

12:30 p.m. – 1:00 p.m.

Microbiome in Parkinson’s Disease
Sarkis Mazmanian, M.D., California Institute of Technology

1:00 p.m. – 1:30 p.m.

Induced Pluripotent Stem Cells/Stem Cells and Parkinson’s Disease Therapy
Lorenz Studer, M.D., Memorial Sloan Kettering Cancer Center

1:30 p.m. – 2:00 p.m.

Question and Answer Panel

2:00 p.m. – 2:15 p.m.

Break

2:15 p.m. – 3:30 p.m.

Breakout Sessions—Working Groups to discuss and report on summary of research gaps and needs from topic fora

Topic: The Burden of GI Dysfunction in Parkinson’s Disease
Leader: Michael Camilleri, M.D.
Facilitator: Frank Hamilton, M.D.
Discussants: TBA

Topic: Top Down or Bottom Up? (Gut-Brain Versus Brain-Gut in the Pathogenesis of Parkinson’s Disease)
Leaders: Kirsteen Browning, Ph.D., and Fredric Manfreddson, Ph.D.
Facilitator: Jon Hollander, Ph.D.
Discussants: TBA

Topic: Mechanisms of Gut Dysfunction in the Enteric Nervous System in Parkinson’s Disease
Leader: Gary Mawe, Ph.D.
Facilitator: Terez Shea-Donohue, Ph.D.
Discussants: TBA

Topic: Diagnostic and Therapeutic Potential of the Gut in Parkinson’s Disease
Leader: John Wiley, M.D.
Facilitator: Patricia Greenwel, Ph.D., Program Director, NIDDK
Discussants: TBA

3:30 p.m. – 4:30 p.m.

Breakout Session Subgroup Presentations by Leaders (15 minutes per subgroup)

4:30 p.m. – 5:00 p.m.

Workshop Summary and Recommendations with Concluding Remarks
NIDDK, NINDS, NIEHS Program

5:00 p.m.

Adjournment