Event Details
Background
Obesity in children continues to increase and to be a major public health problem, with the prevalence among youth ages to 2–19 years estimated to be nearly 20 percent. Racial and ethnic disparities in prevalence remain significant, with non-Hispanic Black and Hispanic children having higher rates of obesity than non-Hispanic White children. Children from families of low socioeconomic status also are disproportionately affected.
The development of obesity is multifactorial, but ultimately it is driven by numerous factors (genetic, epigenetic, behavioral, and environmental) that favor a positive energy balance. As such, several behavioral and lifestyle obesity-prevention and treatment interventions for children that target diet and activity have been tested, yet most of these interventions show only modest favorable changes in body mass index, which are not sustained. Substantial inter-individual differences exist in response to interventions, but we cannot reliably predict who will or will not respond to a given intervention strategy.
Furthermore, a substantial proportion of children who have obesity early in life will continue to have obesity in later years, and studies have shown that accelerated growth patterns during infancy and early childhood are associated with a higher risk of overweight or obesity in adolescence and adulthood. High-risk growth trajectories or patterns emerge during infancy and early childhood and tend to persist, suggesting that this is a critical period in the development of overweight and obesity. Significant progress has been made in identifying behavioral, biological, psychosocial, and environmental factors that place children at a higher or lower risk of developing obesity. For example, epidemiologic studies have provided evidence that the development of obesity and other chronic diseases begins in utero. Pre-pregnancy obesity, obesity during pregnancy, excessive weight gain during pregnancy, and gestational diabetes all contribute to obesity risk during infancy and childhood and to the risk of chronic diseases in offspring. However, current risk-prediction models that incorporate both known gene variants and maternal risk factors, as well as early life traditional risk factors, are not accurate enough to predict or distinguish who will or will not develop obesity. The complex mechanisms that underlie how these risk factors contribute to excess weight gain or adiposity within individuals are not well understood and need to be investigated.
Meeting Objectives
The overall goal of this trans-NIH workshop is to accelerate research to better characterize early-life risk factors and determine underlying causal mechanisms through which these factors contribute to the development of obesity during childhood.
This meeting will bring together scientists with expertise in systems biology, genetics, pediatric obesity, endocrinology, epidemiology, computational biology, neuropsychology, developmental psychology, behavioral medicine, and other disciplines to discuss (1) what is known regarding the epidemiology and underlying biological and behavioral mechanisms for rapid weight gain and the development of obesity in early life and (2) what new approaches, such as the use of integrated omics, can be or have been used to improve risk prediction and gain novel insights into the causes of obesity in early life. Participants will identify gaps, opportunities, and approaches for future research to better characterize risk and identify causal mechanisms for the development of obesity in early life. Ultimately, this research can inform the development of innovative, targeted, and more effective strategies for childhood obesity prevention.
Sponsor
This workshop is supported by funds from the National Institute of Diabetes and Digestive and Kidney Diseases.
Workshop Co-Chairs
Shari L. Barkin, M.D., M.S.H.S.
William K. Warren Foundation Chair in Medicine
Marian Wright Edelman Professor of Pediatrics
Director, Division of General Pediatrics
Vanderbilt University School of Medicine
Charles F. Burant, M.D., Ph.D.
Robert C. and Veronica Atkins Professor of Metabolism
Professor of Internal Medicine and Molecular and Integrative Physiology
Director, University of Michigan Metabolomics and Obesity Center
Director of the Taubman Institute
University of Michigan School of Medicine
Susan Carnell, Ph.D.
Associate Professor of Psychiatry and Behavioral Sciences
Johns Hopkins University School of Medicine
National Institutes Of Health Organizing Committee Members
National Institute of Diabetes and Digestive and Kidney Diseases
Voula Osganian, M.D., Sc.D., M.P.H. (Chair)
Susan Yanovski, M.D.
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Andrew Bremer, M.D., Ph.D., M.A.S.
Ashley Vargas, Ph.D., M.P.H., R.D.N.
National Heart, Lung, and Blood Institute
Charlotte Pratt, Ph.D., R.D.
Office of Behavioral and Social Sciences Research
Christine Hunter, Ph.D., ABPP
Deborah Young-Hyman, Ph.D.
Office of Disease Prevention
Jacqueline Lloyd, Ph.D., M.S.W.
Registration Deadline
April 22, 2021
Abstracts
Lightning Talk Presentations
Persistently Altered Metabolome in Non-Human Primate Offspring Exposed to Maternal High Fat Diet (mHFD)
Erin E. Bolte, M.Sc.1,4,5; Thomas Horvath, Ph.D.2,3; Maxim Seferovic, Ph.D.4; Sigmund Haidacher, B.S.2,3; Kathleen Hoch, B.S.2,3; Derek O’Neil, Ph.D.4; Anthony Haag, Ph.D.2,3; Kjersti M. Aagaard, M.D., Ph.D.1,4,5
1Translational Biology and Molecular Medicine Program, Baylor College of Medicine (BCM), Houston, TX, USA; 2Department of Pathology and Immunology, BCM and Texas Children’s Hospital (TCH), Houston, TX, USA; 3Texas Children’s Microbiome Center Mass Spectrometry Laboratory, TCH; 4Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, BCM; 5Medical Scientist Training Program, BCM
Protective Effects of Prenatal Social Support on the Intergenerational Transmission of Obesity in Hispanic Families with Low Income
Michelle W. Katzow, M.D., M.S.;1 Mary Jo Messito, M.D.,2 Alan L. Mendelsohn, M.D.,2 Marc Scott, Ph.D.,3 Rachel S. Gross, M.D., M.S.2
1Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; 2New York University Grossman School of Medicine, New York, NY, USA; 3New York University Steinhardt School of Culture, Education, and Human Development, New York, NY, USA
Classifying How the Maternal Lipidome Across Pregnancy Shapes Infant Development
Jennifer L. LaBarre Ph.D., M.P.H., R.D.1,2; Gayatri R. Iyer3; Carolyn F. McCabe Ph.D.2,4; Jaclyn M. Goodrich Ph.D.4; Dana C. Dolinoy Ph.D.2,4; Vasantha Padmanabhan Ph.D.2,4,5; Alla Karnovsky Ph.D.3; and Charles F. Burant M.D., Ph.D.1,2
1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; 2Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA; 3Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA; 4Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA; 5Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
A Prospective Population-based Study of Hypothalamic Gliosis, Obesity, and Weight Gain in Children
Leticia Sewaybricker, M.D., Ph.D.1; Sarah Kee1; Susan Melhorn, Ph.D. 1; Susan Carnell, Ph.D. 2; Christian Roth, M.D. 3; Ellen Schur, M.D., M.S. 1
1Department of Medicine, University of Washington, Seattle, WA, USA; 2Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA; 3Department of Pediatrics, Seattle Children’s Research Institute, Seattle, WA, USA
FTO Obesity Risk Allele Influences Brain Structure in Children
Gita Thapaliya, Ph.D.1; Elena Jansen, Ph.D.1; Jennifer R. Sadler, Ph.D.1; Matthew J. Huentelman, Ph.D. 2,3, Marcus A. Naymik3, Ph.D. Muriel Bruchhage, Ph.D.4,5, Sean C. L. Deoni, Ph.D.4,5,6, Susan Carnell, Ph.D.1
1Division of Child and Adolescent Psychiatry, Department of Psychiatry, and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA, 2Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA, 3Neurogenomics Division, TGen, Phoenix, AZ, USA. 4Advanced Baby Imaging Lab, Hasbro Children’s Hospital, Rhode Island Hospital, Providence, RI, USA, 5Department of Pediatrics, Warren Alpert Medical School at Brown University, Providence, RI, USA, 6Maternal, Newborn and Child Health Discovery & Tools, Bill & Melinda Gates Foundation, Seattle, WA, USA
Infant Appetite Traits, Feeding Practices, and Child Obesity in Low-Income Hispanic Families
Sarvenaz Vandyousefi, Ph.D., M.S., R.D.1; Mary Jo Messito, M.D.1; Michelle W.
Katzow M.D., M.S.2; Marc A. Scott, Ph.D.3; and Rachel S. Gross, M.D., M.S.1
1Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA; 2Department of Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Cohen Children’s Medical Center, Hempstead, NY, USA; 3Department of Applied Statistics, Social Science, and Humanities, New York University Steinhardt School of Culture, Education, and Human Development, New York, NY, USA
Poster Presentations
Baby Feed: A Web Application for Health Professionals and Researchers to Easily Evaluate Infant and Toddler Diets
Jennifer A. Bolton, M.S.; and Cristina Palacios, Ph.D.
Florida International University, Miami, FL, USA
Prevalence of Hyperpalatable Baby Foods in the U.S. Food System and Exposure During Infancy
Tera L. Fazzino, Ph.D.1,2; Kaitlyn Rohde, B.S.1,2; Katherine S. Morris, M.S.3; Kai Ling Kong, Ph.D.4
1Department of Psychology, University of Kansas, Lawrence, KS, USA; 2Cofrin Logan Center for Addiction Research and Treatment, University of Kansas, Lawrence, KS, USA; 3Division of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; 4Division of Health Services and Outcomes Research, Children’s Mercy Hospital, Kansas City, MO, USA
Differences in Metabolite Levels Across Adolescence Underlie in utero Exposure to Maternal Obesity or Gestational Diabetes Mellitus: A Prospective Study in the EPOCH Cohort
Ellen C. Francis, Ph.D.1; Katerina Kechris, Ph.D.2; Mohammad L. Rahman, Ph.D.3; Dana Dabelea, Ph.D.1,4; Wei Perng, Ph.D.1,4
1Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora CO, USA; 2Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; 3Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA; 4Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, CO, USA
Socioeconomic Disadvantage and Child Food Approach: Investigating Mediation by Parental Non-Responsive Feeding Practices
Elena Jansen, Ph.D.1, Gita Thapaliya, Ph.D.1, Jennifer R. Sadler, Ph.D.1, Sean C. L. Deoni, Ph.D.2,3,4, Susan Carnell, Ph.D.1
1Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore MD, USA; 2Advanced Baby Imaging Lab, Hasbro Children’s Hospital, Rhode Island Hospital, Providence, RI, USA; 3Department of Pediatrics, Warren Alpert Medical School at Brown University, Providence, RI, USA; 4Maternal, Newborn and Child Health Discovery & Tools, Bill & Melinda Gates Foundation, Seattle, WA, USA
Association Between Added Sugars from Infant Formulas and Rapid Weight Gain in U.S. Infants and Toddlers
Kai Ling Kong, Ph.D.1; Brenda Burgess, Ph.D.2, Katherine S. Morris, M.S., R.D.2, Tyler Re, B.S.1, Holly R Hull, Ph.D.3, Debra K. Sullivan, Ph.D., R.D.3, Rocco A. Paluch, M.S.2
1Division of Health Services and Outcomes Research, Children’s Mercy Hospital, Department of Pediatrics, University of Missouri- Kansas City, Kansas City, MO, USA; 2Division of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; 3Department of Dietetics and Nutrition, Kansas University Medical Center, University of Kansas, Kansas City, KS, USA
Changes in Dietary Quality and Association with BMI in Fourth Grade Children Followed Over a Period Ranging from 2.5 to 5.5 years
Ying Meng, Ph.D., R.N.1; Barbara Lohse, Ph.D., R.D.2; Diane C. Mitchell, M.S., R.D.3; Leslie Cunningham-Sabo, Ph.D., R.D.4
1School of Nursing, University of Rochester, Rochester, NY, USA; 2Wegmans School of Health and Nutrition, Rochester Institute of Technology, Rochester, NY, USA; 3Diet Assessment Center, Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA; 4Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA
Sweet and Salty Snack Intake Associated with Infant WFL Z-scores
Amy M. Moore, Ph.D., R.D.1; Jennifer Orlet Fisher, Ph.D.2; Katherine S. Morris, M.S., R.D.3; Christina M. Croce, M.S., D.T.R.2; Kai Ling Kong, Ph.D.4,5,6
1Center for Childhood Obesity Research, The Pennsylvania State University, 129 Noll Laboratory, University Park, PA, USA; 2Department of Social and Behavioral Sciences, Center for Obesity Research and Education, College of Public Health, Temple University, 3223 N. Broad Street, Suite 175, Philadelphia, PA, USA; 3Division of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; 4Baby Health Behavior Lab, Division of Health Services and Outcomes Research, Children’s Mercy Research Institute, Children’s Mercy Hospital, Kansas City, MO, USA; 5Department of Pediatrics, University of Missouri-Kansas City, Kansas City, MO, USA; 6Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS, USA
Maternal Disordered Eating and Problematic Eating Behaviors of Children Undergoing Weight Loss Treatment: A Cluster Analysis
Sofia Ramalho, Ph.D.1; Sílvia Félix, M.Sc.1; Andrea B. Goldschmidt, Ph.D.2; Diana Silva, Ph.D.3; Cristiana Costa, M.Sc.3; Helena Ferreira Mansilha, M.D.4, Eva Conceição, Ph.D.1;
1University of Minho, School of Psychology, Portugal; 2Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Weight Control and Diabetes Research Center/The Miriam Hospital, Providence, RI, USA; 3Centro Hospitalar Universitário de São João, Portugal; 4Centro Hospitalar e Universitário do Porto – Centro Materno Infantil do Norte (CMIN), Portugal
Clustering of Appetitive and General Self-Regulation Traits and Cross-Sectional Associations with Weight and Diet Outcomes
Jennifer R. Sadler, Ph.D.1, Elena Jansen, Ph.D.1, Gita Thapaliya, Ph.D.1, Sean C. L. Deoni, Ph.D.2,3,4, Susan Carnell, Ph.D.1
1Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore MD, USA; 2Advanced Baby Imaging Lab, Hasbro Children’s Hospital, Rhode Island Hospital, Providence, RI, USA; 3Department of Pediatrics, Warren Alpert Medical School at Brown University, Providence, RI, USA; 4Maternal, Newborn and Child Health Discovery & Tools, Bill & Melinda Gates Foundation, Seattle, WA, USA
