Event Details
Agenda
Abstracts
Event Details
Meeting Objectives
The goal of this 1.5-day workshop will be to gather clinical and basic science investigators who are interested in diseases of the exocrine and/or endocrine pancreas and in achieving an understanding of how the two compartments interact in disease. This workshop will provide an opportunity for investigators in exocrine diseases to come together with those studying islets in diabetes as a means to foster interdisciplinary discussion and identify areas for advancement.
Registration Deadline
June 13, 2022
Abstract Deadline
May 20, 2022
Agenda
June 29, 2022
- 8:00 a.m. – 8:05 a.m.
- Welcome and Introduction of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Director
Teresa Mastracci, Ph.D., Indiana University–Purdue University Indianapolis
Maike Sander, M.D., University of California, San Diego (UCSD)
Stephen Pandol, M.D., Cedars-Sinai Medical Center
- 8:05 a.m. – 8:15 a.m.
- Welcome
Griffin P. Rodgers, M.D., MACP, Director, NIDDK
- 8:15 a.m. – 8:25 a.m.
- Workshop Goals
Teresa Mastracci, Ph.D., Indiana University–Purdue University Indianapolis
Maike Sander, M.D., University of California, San Diego (UCSD)
Stephen Pandol, M.D., Cedars-Sinai Medical Center
- 8:25 a.m. – 8:40 a.m.
- Overview of Pancreas Anatomy, Physiology, and Function—Synergy between the Endocrine and Exocrine Compartments
David Whitcomb, M.D., Ph.D., University of Pittsburgh
Session One: New Insights into Pancreas Anatomy and Physiology
Moderators: David Whitcomb, M.D., Ph.D., University of Pittsburgh, and Al Powers, M.D., Vanderbilt University
- 8:40 a.m. – 9:00 a.m.
- New Insights into the Development and Maturation of the Human Pancreas
Alejandro Caicedo, Ph.D., University of Miami
- 9:00 a.m. – 9:20 a.m.
- Vascular Flow and Regulation
Manami Hara, Ph.D., The University of Chicago
- 9:20 a.m. – 9:40 a.m.
- Neuronal/Innervation (Virtual Presentation)
Abdelfattah El Ouaamari, Ph.D., M.Sc., Rutgers University
- 9:40 a.m. – 10:00 a.m.
- Stellate Cells (Virtual Presentation)
Minote Apte, M.B.B.S., Ph.D., M.Med.Sci, University of New South Wales, Australia
- 10:00 a.m. – 10:15 a.m.
- Abstract Presentation: MRI Reflects Increases in Pancreas Perfusion Following Glucose Ingestion
Chengyue Wu, Ph.D., University of Texas at Austin
- 10:15 a.m. – 10:30 a.m.
- Moderator-directed Panel Discussion
- 10:30 a.m. – 10:50 a.m.
- Break
Session Two: Diabetes in the Setting of Exocrine Disease
Moderators: Melena Bellin, M.D., University of Minnesota, and Søren Olesen, M.D., Ph.D., Aalborg University, Denmark
- 10:50 a.m. – 11:10 a.m.
- Diabetes after Acute Pancreatitis
Dhiraj Yadav, M.D., M.P.H., University of Pittsburgh
- 11:10 a.m. – 11:40 a.m.
- Diabetes after Chronic Pancreatitis
Mark Goodarzi, M.D., Ph.D., Cedars-Sinai Medical Center
- 11:40 a.m. – 12:10 p.m.
- Cystic Fibrosis–related Diabetes
Rebecca Hull, Ph.D., University of Washington
- 12:10 p.m. – 12:25 p.m.
- Abstract Presentation: Molecular Changes Underlying Islet Dysfunction and Diabetes in Chronic Pancreatitis
Yan Hang, Ph.D., Stanford University
- 12:25 p.m. – 12:40 p.m.
- Moderator-directed Panel Discussion
- 12:40 p.m. – 1:30 p.m.
- Lunch
- 1:30 p.m. – 2:30 p.m.
- Poster Session
Session Three: Metabolic Influences on the Exocrine Pancreas
Moderators: Ernesto Bernal-Mizrachi, M.D., University of Miami, and Stephen Pandol, M.D., Cedars-Sinai Medical Center
- 2:30 p.m. – 2:50 p.m.
- Beta Cell Drivers of Pancreatic Cancer
Mandar Muzumdar, M.D., Yale University
- 2:50 p.m. – 3:10 p.m.
- Obesity and Pancreatic Ductal Adenocarcinoma
Zobeida Cruz Monserrate, Ph.D., The Ohio State University
- 3:10 p.m. – 3:30 p.m.
- Decreased Exocrine Mass in Type 1 Diabetes (Virtual Presentation)
Martha Campbell-Thompson, D.V.M., Ph.D., University of Florida
- 3:30 p.m. – 3:50 p.m.
- Effects of Hyperinsulinism on Exocrine Cells
Janel Kopp, Ph.D., University of British Columbia, Canada
- 3:50 p.m. – 4:10 p.m.
- Acinar Cell Heterogeneity
Steven Artandi, M.D., Ph.D., Stanford University
- 4:10 p.m. – 4:25 p.m.
- Abstract Presentation: Murine Pancreatic Acinar Cells Require Expression of Tff2 to Support Beta Cell Development and Function During Aging
Jose Ortiz, City of Hope National Medical Center
- 4:25 p.m. – 4:40 p.m.
- Moderator-directed Panel Discussion
- 4:40 p.m. – 5:00 p.m.
- Break
Session Four: Genetic Drivers of Pancreatic Diseases
Moderators: Kyle Gaulton, Ph.D., UCSD, and Laufey Amundadottir, Ph.D., National Cancer Institute
- 5:00 p.m. – 5:20 p.m.
- Genetic Drivers of Exocrine Disease
Andrea Geisz, Ph.D., Boston University
- 5:20 p.m. – 5:40 p.m.
- Genetic Drivers of Diabetes
Kyle Gaulton, Ph.D., UCSD
- 5:40 p.m. – 6:00 p.m.
- Genetic Drivers of Pancreatic Cancer
Alison Klein, Ph.D., M.H.S., Johns Hopkins University
- 6:00 p.m. – 6:15 p.m.
- Abstract Presentation: The Human Genetic Risk Factor CEL-HYB1 Causes Endoplasmic Reticulum Stress, Chronic Pancreatitis and Impaired Glucose Tolerance in Mice
Anders Molven, Ph.D., University of Bergen, Norway
- 6:15 p.m. – 6:35 p.m.
- Moderator-directed Panel Discussion
- 6:35 p.m.
- Day 1 Adjournment
June 30, 2022
Session Five: Tools for Integrated Pancreatic Analysis
Moderators: Cherie Stabler, Ph.D., University of Florida
- 8:00 a.m. – 8:20 a.m.
- Histology in the Pancreas and Magnetic Resonance Imaging Biomarkers
Temel Tirkes, M.D., Indiana University
- 8:20 a.m. – 8:40 a.m.
- Organoid and Pancreas on Chip
Alex Kleger, M.D., Ulm University, Germany
- 8:40 a.m. – 9:00 a.m.
- 3D Imaging Study and Mapped Changes in Innervation in Type 2 Diabetes (Virtual Presentation)
Alexandra Alvarsson, Ph.D., Icahn School of Medicine at Mount Sinai
- 9:00 a.m. – 9:20 a.m.
- Pancreas Slices to Study Interactions between Immune Cells and Islets
Ed Phelps, Ph.D., University of Florida
- 9:20 a.m. – 9:40 a.m.
- Abstract Presentation: In Situ Study of Endocrine and Exocrine Cell Function in Recent-Onset T1D and At-Risk AAb+ Organ Donors
Denise Drotar, Ph.D., University of Florida
- 9:40 a.m. – 10:00 a.m.
- Moderator-directed Panel Discussion
- 10:00 a.m. – 10:20 a.m.
- Break
Session Six: Implications of Endocrine/Exocrine Crosstalk
Moderators: Scott Oakes, M.D., The University of Chicago and Anjaparavanda P. Naren, Ph.D., Cedars-Sinai Medical Center
- 10:20 a.m. – 10:40 a.m.
- Exocrine Ductal System and Cystic Fibrosis–related Diabetes
Anjaparavanda P. Naren, Ph.D., Cedars-Sinai Medical Center
- 10:40 a.m. – 11:00 a.m.
- CHOP/DDIT3 Depletion in Pancreatic β Cells Restrains PDAC Development and Metastasis to Liver
Jing Yong, Ph.D., Sanford Burnham Medical Research Institute
- 11:00 a.m. – 11:20 a.m.
- Exocrine Influences on Islet Function and Diabetes
Rohit Kulkarni, M.D., Ph.D., Joslin Diabetes Center and Harvard University
- 11:20 a.m. – 11:40 a.m.
- Translational Regulation of Exocrine–Endocrine Cross Talk
Teresa Mastracci, Ph.D., Indiana University–Purdue University Indianapolis
- 11:40 a.m. – 11:55 a.m.
- Abstract Presentation: Serum Exocrine Enzymes as Biomarkers of Response to Immunotherapy in Type 1 Diabetes
Brittany S. Bruggeman, M.D., University of Florida
- 11:55 a.m. – 12:15 p.m.
- Moderator-directed Panel Discussion
- 12:15 p.m. – 12:30 p.m.
- Closing Summary of Workshop
Teresa Mastracci, Ph.D., Indiana University–Purdue University Indianapolis
Maike Sander, M.D., University of California, San Diego (UCSD)
Stephen Pandol, M.D., Cedars-Sinai Medical Center
- 12:30 p.m.
- Adjournment
Abstracts
Submission Deadline
May 20, 2022
Submitting Abstracts
All abstracts must be submitted via email to Rachel Pisarski, with “Abstract-NIDDK Exocrine Endocrine Pancreas Workshop” in the subject line. The abstract submission should be a 1-page Microsoft Word document that does not exceed 250 words (not including the abstract’s title and name and affiliation of all authors).
Download the Abstract Template (DOCX, 24.16 KB) .
Abstract Organization
Organize the body of the abstract as follows:
- Statement of the study’s purpose
- Statement of the methods used
- Summary of the results presented in sufficient detail to support the conclusion
- Statement of the conclusions reached, including any related to exocrine-endocrine pancreas interactions
Formatting Requirements
Please follow the instructions below to format an abstract. (Note: Submissions will not be edited for spelling or grammar and will be accepted “as is.”)
- The abstract should be a Microsoft Word document with 1-inch margins, typed single space, using Times New Roman font; a 12-point font should be used for everything except the title.
- The abstract’s title should be Typed in Title Case using Bold 16-Point font, and it should clearly represent the nature of the investigation. Do not use subheadings (e.g., Methods, Results) in the body of the abstract.
- Skip one line after the title, and list the author’s first and last names, degree, affiliation, city, state, and country. Separate multiple authors with a semicolon, and underline the primary author’s name (one primary author per abstract).
- Use one blank line between the title and the authors, the authors and the body of the abstract, and between paragraphs.
- Please ensure that your abstract is the correct length (no longer than 250 words).
- Use standard abbreviations (e.g., RBC) and standard symbols for units of measure (e.g., kg, g, mg, mL, L, and %). Place abbreviations and acronyms in parentheses after the full word the first time that the term appears. Use numerals to indicate numbers, except as the first word of a sentence.
- Simple tables or graphs may be included; however, the abstract may not be longer than one page, including any tables or graphs.
Abstract Presentations
Select Abstracts will be chosen for short talks during the workshop and submitting authors will be notified in advance. Others will be invited for a poster presentation to be brought in-person and presented during poster sessions at the workshop. Abstracts selected for talks will be requested to provide a brief written summary of the talk in advance, to contribute to a conference summary that will be prepared after the meeting.
