We use optical approaches to investigate receptor signaling in neural circuits controlling motivation and salience.

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Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding.
Singh Alvarado J, Lutas A, Madara JC, Isaac J, Lommer C, Massengill C, Andermann ML.
Neuron (2024 May 1) 112:1416-1425.e5. Abstract/Full Text
History-dependent dopamine release increases cAMP levels in most basal amygdala glutamatergic neurons to control learning.
Lutas A, Fernando K, Zhang SX, Sambangi A, Andermann ML.
Cell Rep (2022 Jan 25) 38:110297. Abstract/Full Text
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Last Reviewed July 2024