About Our Research
The Genetics of Development and Disease Section seeks to understand sphingolipid metabolism in health and disease. Sphingolipid metabolism has essential roles during organism development and homeostasis. When the pathway is disturbed by genetic mutations, human diseases result that often include neurodegeneration. Our work is aimed at identifying how the altered sphingolipid pathway causes disease and developing treatments to correct the genetic defects.
Current Research
Our lab currently studies:
- How sphingolipids cause human disease when their metabolic pathway is disrupted.
- How to correct to genetic defects in diseases of sphingolipid metabolism.
The goal of this research is to gain fundamental knowledge about important biological processes that will help us understand the basis of human diseases.
This research will lead to the development of new therapies for human diseases.
Journal Cover Art
![2023 cover of the Journal of Lipid Research.](/-/media/Images/labs-branches-sections/genetics-biochemistry-branch/Genetics-of-Development-and-Disease-Section/journal-lipid-research-2023-cover_1700x2200.jpg)
![2014 cover of the Journal of Lipid Research.](/-/media/Images/labs-branches-sections/genetics-biochemistry-branch/Genetics-of-Development-and-Disease-Section/journal-lipid-research-2014-cover_2525x3271.jpg)
![2014 cover of the Journal of Clinical Investigation.](/-/media/Images/labs-branches-sections/genetics-biochemistry-branch/Genetics-of-Development-and-Disease-Section/journal-clinical-investigation-2014-cover_2378x3149.jpg)
![2013 cover of the Journal of Biological Chemistry.](/-/media/Images/labs-branches-sections/genetics-biochemistry-branch/Genetics-of-Development-and-Disease-Section/journal-biological-chemistry-2013-cover_2474x3238.jpg)
![Cover of Molecular Genetics and Metabolism.](/-/media/Images/labs-branches-sections/genetics-biochemistry-branch/Genetics-of-Development-and-Disease-Section/molecular-genetics-metabolism-cover_2347x3201.jpg)
![2004 cover of the Journal of Biological Chemistry.](/-/media/Images/labs-branches-sections/genetics-biochemistry-branch/Genetics-of-Development-and-Disease-Section/journal-biological-chemistry-2004-cover_2464x3207.jpg)
![Cover of Human Molecular Genetics.](/-/media/Images/labs-branches-sections/genetics-biochemistry-branch/Genetics-of-Development-and-Disease-Section/human-molecular-genetics-cover_2421x3319.jpg)
![2000 cover of the Journal of Clinical Investigation.](/-/media/Images/labs-branches-sections/genetics-biochemistry-branch/Genetics-of-Development-and-Disease-Section/journal-clinical-investigation-2000-cover_2438x3228.jpg)
![Cover of Molecular Medicine Today.](/-/media/Images/labs-branches-sections/genetics-biochemistry-branch/Genetics-of-Development-and-Disease-Section/molecular-medicine-today-cover_1694x2193.jpg)