Section Chief: Daniel Appella, Ph.D.
Research Materials & Patents
Patents, materials, and other research resources appear below. Some resources may be available for use through Material Transfer Agreements (MTAs) or licensing agreements.
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Anti-HIV Acylthiol & Thioether prodrugs (U.S. Patent Number 12/414,321)
These inventions provide the compositions, pharmaceutical carrier, and usages of the new Acylthiols (E-329-2000 family) and Thioether pro-drug (E-177-2010 family) compounds in treatment of retroviral infections such as HIV. These compounds target the… -
PNA-Detection of Pathogens (U.S. Patent Number 13/592,490)
The laboratory of Daniel Appella, PhD. has developed a prototype HIV testing kit that employs a peptide nucleic acid probe to capture HIV RNA recovered from patient blood. The probe targets a highly conserved segment of the Gag sequence. Initial data… -
Programmable self-assembled nanostructures based on sidechain-modified pna for the multivalent display of ligands (U.S. Patent Number EP 2569328 A2)
The invention concerns compositions comprising strands of polynucleotide and strands of PNA, each PNA strand comprising: (i) from 2 to 50 nucleobase subunits and (ii) one or more gamma substituents. The PNA strands are complementary to at least a… -
Sidechain Functionalized S-acylbenzamides With Anti-HIV Activity
HIV infection remains a major medical problem, with approximately 38 million people worldwide living with HIV. Nipamovir and SAMT-247 are simple and inexpensive small molecules that inactivate HIV virus by interference with final maturation steps of…E-032-2023-0
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Thyclotide Peptide Conjugates with Cell Permeability & Inhibitory Activity
Thyclotides are oligomeric molecules with chiral tetrahydrofuran (THF) diamine units consisting of either R,R or S,S stereochemistry. Thyclotide sequences with R,R stereochemistry bind to complementary DNA and RNA sequences with strong affinity and…E-033-2023-0
Last Reviewed February 2024