About the Lab

LERB investigates transcriptional and epigenomic mechanisms underlying the development of endocrine systems and the actions of hormones and their nuclear receptors.

Current Research

The Adipocyte Biology and Gene Regulation Section investigates epigenomic regulation of gene expression and cell differentiation, with a focus on histone modifying and chromatin remodeling enzymes that regulate enhancers. The Section also studies epigenomic regulation of adipose tissue development and expansion. The resulting knowledge may lead to novel ways to treat obesity and type 2 diabetes.

The Nuclear Receptor Biology Section investigates the mechanisms by which thyroid hormone elicits its cell-specific actions as a prerequisite to understanding the basis of thyroid disorders. Ultimately, this knowledge may aid in the design of improved treatments for thyroid diseases.