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  6. Section on Nuclear Mechanotransduction & Cell Fate Dynamics

Section on Nuclear Mechanotransduction & Cell Fate Dynamics

of the Laboratory of Molecular Biology

Kate Miroshnikova. Yekaterina (Kate) Miroshnikova, Ph.D., Stadtman Tenure-Track Investigator

Section Chief

yekaterina.miroshnikova@nih.gov
We employ interdisciplinary approaches to uncover the role of mechanical forces in regulating chromatin and nuclear architecture and gene expression to modulate stem cell fate.
About Our Research

Select Publications

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.
Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Dahl KN, Wickström SA.
Cell (2020 May 14) 181:800-817.e22. Abstract/Full Text NIH external link
Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification.
Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Kamprad N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA.
Nat Cell Biol (2018 Jan) 20:69-80. Abstract/Full Text NIH external link
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Last Reviewed June 2024