Understanding perturbed immunoregulation in diseases of autoimmunity and manipulating the balance between inflammatory and regulatory immune responses.

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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection.
Desai JV, Kumar D, Freiwald T, Chauss D, Johnson MD, Abers MS, Steinbrink JM, Perfect JR, Alexander B, Matzaraki V, Snarr BD, Zarakas MA, Oikonomou V, Silva LM, Shivarathri R, Beltran E, Demontel LN, Wang L, Lim JK, Launder D, Conti HR, Swamydas M, McClain MT, Moutsopoulos NM, Kazemian M, Netea MG, Kumar V, Köhl J, Kemper C, Afzali B, Lionakis MS.
Cell (2023 Jun 22) 186:2802-2822.e22. Abstract/Full Text
Autocrine vitamin D signaling switches off pro-inflammatory programs of T(H)1 cells.
Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova-Lamperti E, Kumar D, Zhang Z, Teague H, West EE, Vannella KM, Ramos-Benitez MJ, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz DM, Portilla D, Chertow DS, John S, Lavender P, Kemper C, Lombardi G, Mehta NN, Cooper N, Lionakis MS, Laurence A, Kazemian M, Afzali B.
Nat Immunol (2022 Jan) 23:62-74. Abstract/Full Text
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Lab Members

Members of the Immunoregulation Section 2024

From left to right, Dhaneshwar Kumar, Christina Taylor, Jianping Ma, Daniel Chauss, Ben Afzali, Isabelle Yang, Md Tajmul (with Anaya Taj), Pranavi Thoom, Didier Portilla, and Luis Trujillo-Ochoa

Photo credit: Jessica Castro Lara

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Last Reviewed October 2023