Research Materials & Patents

1. Bcl-x LoxP (Bcl2l1 tm1.1Mam) Mouse

   Floxed Bcl-x: Conditional knockout of pro-survival Bcl-x in primordial germ cells was used to study the balance between pro-aptoptotic Bax during embryogenesis.Bcl-x is a pro-survival protein that opposes the pro-apoptotic action of Bax which…
   Summary
   PI: Hennighausen, Lothar

2. Stat1LoxP (Stat1 tm1Mam) Mouse

   Selective inactivation of Stat 1 in mammary cells indicates that its effect as a tumor suppressor in breast is direct.STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by…
   Summary
   PI: Hennighausen, Lothar

3. Stat5a KO(Stat5a tm1Mam) Mouse

   Stat 5a Knockout: Stat5a deficiency results in the loss of prolactin-dependent mammary gland development and lactogenesis. Prolactin induces mammary gland development and lactogenesis. Binding of Prolactin to its receptor leads to the phosphorylation…
   Summary
   PI: Hennighausen, Lothar

4. Stat5a LoxP/Stat5b LoxP (Stat5a/Stat5b tm2Mam) Mouse

   Conditional knockout of Stat5a and Stat5b: Combined deletion of conserved Stat5a and Stat5b in mammary epithelium at different times during pregnancy reveal multiple distinct functions.The signal transducer and activator of transcription (STAT…
   Summary
   PI: Hennighausen, Lothar

5. Tg(MMTV-Cre)#Mam Mouse

   Cre-recombinase under the control of mouse mammary tumor virus long terminal repeat (MMTV) was expressed in the salivary gland and mammary epithelial cells of adult mice, and induced recombination in all tissues.The Cre recombinase from bacteriophage…
   Summary
   PI: Hennighausen, Lothar

6. Tg(Wap-cre)11738Mam Mouse

   Cre-recombinase under the control of the whey acidic acid protein was only detected in alveolar epithelial epithelial cells of mammary tissue during lactation, and transcription occurred at all stages of mammary development.The Cre recombinase from…
   Summary
   PI: Hennighausen, Lothar